After sinus surgery, it is important to use nasal packing to help control bleeding and provide support to separate tissue and structure at the surgical site. The device comprises bis(hydroxyl)-terminated PLA-PEG-PLA. This device functions to fill nasal/sinus cavities following surgery or trauma and to keep mucosal surfaces separate during the healing process.
Injectable Poly-DL-lactic Acid | DL10014A | CAS No- 26023-30-3
Poly(L-lactide-co-ε-caprolactone) | PLCL | CAS No : 65408-67-5 Biodegradable, biocompatible, and bioresorbable copolymer
Biodegradable thermosensitive polymer, poly(dl-lactide-co-glycolide-b-ethylene glycol-b-dl-lactide-co-glycolide) (PLGA-PEG-PLGA) is a desirable ophthalmic drug delivery system because it can be formulated into an injectable solution which forms a gel in situ to provide prolonged drug release.
The hydrogel polymer is an application-tailored PLGA-PEG-PLGA triblock polymer.
The polymer molecule exhibits a hydrophilic core region and hydrophilic ends. An aqueous solution of this polymer is reverse thermosensitive, meaning it is fluid and injectable at room temperature and will rapidly form a hydrogel at body temperature (e.g. after subcutaneous injection).
The polymer is biodegradable due to the instability of ester bonds in the aqueous physiological environment. This process continues at a slow rate and will eliminate the hydrogel from the body in several weeks in a non-toxic way.