+91 97731 34699 [email protected]


Well known manufacturer &
supplier in India

Cost-effective PLGA and PLA nanoparticles for Drug formulation as nanomedicine and biodegradable orthopedic implants

Since its commencement, Nomisma Healthcare has acquired abilities and specialization with business backing to give its customers precise data and outstanding items as regards. With highly qualified experts, the Nomisma group has a brilliant conception of the complexities of the market and has firm associations with key collaborators to take the organization forward.

At Nomisma Healthcare, PLGA i.e. Poly (lactic-co-glycolic) acid and PLA i.e. Polylactic acid Nanoparticles based polymers, are manufactured at our ISO 9001-2015 certified facility, meeting the desired quality standards for its efficient & successful use.

We offer in both, the small and large scale quantities of biopolymers. We provide the best quality biodegradable polymers to become trustable global polymer suppliers, meeting the products with international pharmaceutical quality standards.

Polylactic acid and Polylactic co Glycolic acids, also referred to as PLA and PLGA, are produced by ring-opening polymerization of corresponding lactide and glycolide monomers with a specific catalyst which is nontoxic. Their degradation properties and a long history of use in human products make PLGA, a desirable product for drug delivery, medical device, and combination products. The Nomisma Healthcare brand has been a reliable and proven source of these products in India and across the globe via a new technology approach at a reasonable price.

At Nomisma healthcare, the range of PLGA incorporates monomer compositions of Lactic acid to glycolic acid like 50:50, 75:25, 85:15, 45:55, etc. in Poly (lactic-co-glycolic) acid. These products are offered in a range of molecular weights, as well as acid, hydroxyl and ester end groups.

For different prerequisites of PLGAs, it would be ideal if you don’t hesitate to contact/write to us. Also, our skilled research team can do the custom synthesis as per customer’s demands by applicable modifications in polymer synthesis.

Polymer Characterization

The Characterization of Polymer, to be used in complex drug formulation, is a key requirement. To fulfill this requirement considering the regulatory aspects, at Nomisma Healthcare, detailed study & analysis are done which covers the following tests.

  • Identification by 1H-NMR
  • Identification by FT-IR
  • Inherent viscosity (IV)
  • Monomer ratio by NMR study
  • End group identification by 13C NM
  • Block length identification by 13C NMR
  • Water content by Karl Fischer
  • Glass transition temperature (Tg) by DSC
  • Free acid content by a titrimetric analysis
  • Residual monomer content by 1H-NMR
  • Bioburden test (total aerobes, spores, and anaerobes)

Poly Lactic-Co-Glycolic Acid (PLGA) as biodegradable controlled drug delivery carrier

PLGA plays an important and Key role play when used in complex drug delivery systems and biodegradable medicinal implants.

Drug loading capacity and degradation time of implant depends on

  • The ratio of lactide to glycolides
  • End group of the polymer
  • Molecular weight polymer chain

Poly L-Lactic acid (PLLA) and Poly DL- Lactic acid (PDLLA) for biomedical devices and implants

Poly L-Lactic acid (PLLA) and Poly-DL-lactic acid (PDLLA) are used as bio-degradable products for films, screws, and pins.

The following important parameters are considered during the manufacturing of such devices.

  • It should be a semi-crystalline or amorphous polymer
  • Molecular weight about 100 kDa to 220 kDa
  • Melting point about 170 – 175°C
  • Glass transition temperature (TG) about 55 – 60°C

Why Nomisma?

Key featuresNomisma Healthcare BrandGlobal BrandMerits of Nomisma Healthcare Brand
Metal contentNontoxic Metals are used for the polymerization reaction.

These metals fall under the class-IV category and it requires less tight control for its content in polymer.

Toxic Metals are used for the polymerization reaction.

These metals fall under class-III category and it requires very tight control for its content in polymer.

Polymer brand with nontoxic metal content is more preferred for the orthopedic implant as well as for drug-loaded with polymers for short- & long-term use.
SolventsClass –III category solvents are used for processing steps during polymer isolation.Class–II category solvents together with Class-III are used for processing steps during polymer isolation.Class-III solvents are less hazardous and more preferred when compared with Class-II solvents.
Product PotencyThe potency test is reported by using the Q-NMR technique with a specified and tight limit.The potency test is either not reported is not considered in release analysis.A more reliable technique is used for the potency test with stringent control.
Product stabilityThe non-lyophilization technique is used for product isolation which renders the product with more shelf life over a period of time.Generally, the lyophilization technique is used for product isolation which renders the product with less shelf life over a period of time.The product has an inherent stability character.
Product deliveryUnique technology delivers higher production which in turn helps to meet product delivery.Restricted batch size leading to lesser production which in turn requires a wide timeline for product delivery.In time delivery of the product.
Product costA unique process with higher production capacity renders less costly.Restricted batch size, use of costlier metal reagents, and lyophilization technique, all together make product costly.Polymer product with Quality & cheaper price makes the end product/project more feasible and less costly.