Hot-melt extrusion(HME)
The molecule in its solid state is mixed with the thermoplastic polymer that is heated (at a temperature above the PLGA/PLA glass transition temperature) and forced through a small orifice called a die to form a rod with a defined diameter.
Process limitations: Low API loading; high temperatures; shear stresses.
Example of manufactured product: Zoladex® (Goserelin acetate)
Nomisma`s Products for Zoladex® (Goserelin acetate): DLG50-2A (PLGA 50:50), DLG50-3A (PLGA 50:50)
