DLG50-2A | PLGA 50:50

CAS 26780-50-7

DLG50-2A is an acid terminated Pharma / Medical Grade copolymer of DL-lactide and Glycolide in a 50:50 molar ratio and with an inherent viscosity midpoint of 0.2 dl/g. It is supplied in the form of white to light tan micronized powder. DLG50-2A is primarily used for drug delivery applications and is suitable for all commonly used formulation techniques.

 

Product Description

CAS Number26780-50-7
Systematic Name1, 4-Dioxane-2, 5-dione-1-DL-3, 6-dimethyl-1, 4-dioxane-2, 5-dione copolymer, Glycolide – lactide copolymer, Glycolide-DL-lactide copolymer, Glycolide-DL-lactide polymer, Lactide – glycolide copolymer, Lactomer, Poly(dl-lactide-co-glycolide), Poly(glycolide – lactide), Poly(glycolide-co-lactide), Polyglactin
Molecular Formula((C3H4O2)m x (C2H2O2)n
EPA Registry NameThe polylactic acid-polyglycolic acid copolymer
Former CAS Number(s):107760-14-5, 119652-89-0, 1255770-56-9, 130953-65-0, 31213-75-9, 339986-68-4
Substance TypePLGA 50:50 | Inherent Viscosity: 0.15-0.25 | Acid terminated | Lactide : Glycolide 50:50 | Mw 05-20 kDa
Biodegradable Polymer, Excipient, Non-Active pharmaceutical ingredient, Nanoparticles.
SynonymPLGA, Poly(D,L-lactide-co-glycolide) acid terminated, Poly(DL-lactide-co-glycolide), acid terminated
ApplicationsDrug delivery formulations

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Specification

Appearance White to off-white powder
Solubility Freely soluble in methylene chloride. Insoluble in water.
FT NMR (PROTON) Should comply
FT IR Should comply
Lactide by NMR 50±2%
Glycolide by NMR 50±2%
Viscosity (1% in CHCl3) Between 0.08-0.21 dL/g
Residual monomer DL-Lactide ≤ 0.5 %
Residual monomer Glycolide ≤ 0.5 %
Residual solvent acetone ≤ 0.1 %
Residual solvent toluene ≤ 890 PPM
Total Residual solvent ≤ 1000 PPM
Acid number 8 - 15 mg KOH/g
Heavy metal ≤ 10 PPM
Class 3 Metal ≤ 200 PPM
PS equivalent mol. weight Mw by GPC 05-20 KDa
Sulphated Ash ≤ 0.1 %
TAMC ≤ 2000 CFU/g
TYMC ≤ 200 CFU/g
Bacterial Endotoxins ≤ 6 EU/g
Self life 2 Years