DLG554G | PLGA 55:45
DLG554G | PLGA 55:45 star Glucose is a Pharma / Medical Grade copolymer of DL-lactide and Glycolide in a 55:45 molar ratio having an inherent viscosity midpoint of 0.45 dl/g. It is supplied in the form of white to light tan micronized powder. DLG554G | PLGA 55:45 is primarily used for the Octreotide Depot microsphere and other drug delivery applications.
Product Description
| CAS Number | 26780-50-7 |
| Systematic Name | 1, 4-Dioxane-2, 5-dione-1-DL-3, 6-dimethyl-1, 4-dioxane-2, 5-dione copolymer, Glycolide – lactide copolymer, Glycolide-DL-lactide copolymer, Glycolide-DL-lactide polymer, Lactide – glycolide copolymer, Lactomer, Poly(dl-lactide-co-glycolide), Poly(glycolide – lactide), Poly(glycolide-co-lactide), Polyglactin |
| Molecular Formula | ((C3H4O2)m x (C2H2O2)n x Glucose |
| EPA Registry Name | 55:45 Poly(DL-lactide-co-glycolide), D-glucose |
| Former CAS Number(s): | 107760-14-5, 119652-89-0, 1255770-56-9, 130953-65-0, 31213-75-9, 339986-68-4 |
| Substance Type | PLGA 55:45 | Inherent Viscosity: 0.40-0.60 | D-Glucose terminated | Lactide : Glycolide 55:45 | Mw 40 kDa Biodegradable Polymer, Excipient, Non-Active pharmaceutical ingredient, Nanoparticles. |
| Synonym | PLGA, Poly(D,L-lactide-co-glycolide) acid terminated, 55:45 Poly(DL-lactide-co-glycolide), D-glucose |
| Applications | Drug delivery formulations, Octereotide Depot 1 month |
Specification
| Appearance | White to off-white powder |
| Solubility | Freely soluble in methylene chloride. Insoluble in water. |
| FT NMR (PROTON) | Should comply |
| FT IR | Should comply |
| Lactide by NMR | 55±2% |
| Glycolide by NMR | 45±2% |
| Viscosity (1% in CHCl3) | Between 0.40-0.60 dL/g |
| Residual monomer DL-Lactide | ≤ 0.5 % |
| Residual monomer Glycolide | ≤ 0.5 % |
| Residual solvent acetone | ≤ 0.1 % |
| Residual solvent toluene | ≤ 890 PPM |
| Total Residual solvent | ≤ 1000 PPM |
| Acid number | ≤6 mg KOH/g |
| Heavy metal | ≤ 10 PPM |
| Tin | ≤ 200 PPM |
| PS equivalent mol. weight Mw by GPC | 45 KDa |
| Sulphated Ash | ≤ 0.1 % |
| TAMC | ≤ 2000 CFU/g |
| TYMC | ≤ 200 CFU/g |
| Bacterial Endotoxins | ≤ 2000 EU/g |
| Self life | 2 Years |
| See also: | PLGA 55:45 |