Dissolution of PLGA in different solvents depending on the L: G ratio.

The PLGA dissolution depends on the polymer concentration, polymer molecular weight, and temperature. The information is based on a PLGA molecular weight of around 50 kDa and a concentration of 2.5% (w/v) at 37 °C. The PLGAs used were all in the DL form, and most of them have acid end-caps. The end-cap does not appear to affect the solvent solubility. The dark blue indicates solubility.