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Chemical Structure

PLGA

Poly(D,L-lactide-co-glycolide)

CAS Number 26780-50-7
Systematic Name: 1, 4-Dioxane-2, 5-dione-1-DL-3, 6-dimethyl-1, 4-dioxane-2, 5-dione copolymer, Glycolide – lactide copolymer, Glycolide-DL-lactide copolymer, Glycolide-DL-lactide polymer, Lactide – glycolide copolymer, Lactomer, Poly(dl-lactide-co-glycolide), Poly(glycolide – lactide), Poly(glycolide-co-lactide), Polyglactin
Molecular Formula: ((C3H4O2)m x (C2H2O2)n
EPA Registry Name: Polylactic acid-polyglycolic acid copolymer
Former CAS Number(s) 107760-14-5, 119652-89-0, 1255770-56-9, 130953-65-0, 31213-75-9, 339986-68-4
Substance Type: PLGA 45 55 | Inherent Viscosity : 0.15 – 0.30 dL/g | Acid terminated  | Lactide : Glycolide 45:55 | Mw 5-20 kDa
Biodegradable Polymer, Excipient, Non-Active pharmaceutical ingredient, Nanoparticles.
Synonym:  PLGA, Poly(D,L-lactide-co-glycolide) acid terminated, Poly(DL-lactide-co-glycolide), acid terminated

Qualitative Analysis

Appearance White to tan colored solid powder
Inherent viscosity (IV) 0.15 – 0.30 dL/g, in chloroform(25 °C)
Lactide by 1H NMR 45% ( ± 2%)
Glycolide by 1H NMR 55% ( ± 2%)

Quantitative Analysis

Assay ≥ 98 %
Residual monomer ≤ 0.2 %
Residual solvent Complies
Heavy metal Complies

Application

Poly(D, L-lactide-co-glycolide)- DLG 45-2A (PLGA) has been one of the most attractive Biodegradable and biocompatible polymers used to fabricate devices for diagnostics and other applications of clinical and basic science research, including vaccine, cancer, cardiovascular disease, and tissue engineering. In addition, PLGA and its copolymers are Essential in designing nanoparticles with desired characteristics such as biocompatibility, biodegradation, particle size, surface properties, drug release, and targetability and exhibit a wide range of erosion times. PLGA has been approved by the US FDA for use in drug delivery complex formulation and biodegradable orthopedic Medical implants.

Reference :

  1. Sahoo S.K., Labhasetwar V.: Nanotech approaches to drug delivery and imaging. Drug Discov Today. 2003, 8(24), 1112-1120.
  2. Wickline S. A., Neubauer A. M., Winter P., Caruthers S., Lanza G.: Applications of nanotechnology to atherosclerosis, thrombosis, and vascular biology, Arteriosclerosis, Thrombosis, and Vascular Biology. 2006, 26(3), 435- 441.
  3. Pinto Reis C., Neufeld R. J., Ribeiro A. J., Veiga F.: Nanoencapsulation I. Methods for preparation of drug-loaded polymeric Nanoparticles, Nanomedicine. 2006, 2, 8-21.
  4. Hawker C. J. Wooley K. L.: Review: The convergence of synthetic organic and polymer chemistries, Science. 2005; 309(5738):1200–1205.
  5. Stevanoviae M., Savile J., Jordoviae B., Uskokoviae D.: Fabrication, in vitro degradation and the release behaviors of poly (DL-lactide-co-glycolide) nanospheres containing ascorbic acid, Colloids, and Surfaces B Biointerfaces. 2007, 59(2), 215-223.
  6. Verger M. L., Fluckiger L., Kim Y. I., Hoffman M., Maincent P.: Preparation and characterization of nanoparticles containing an antihypertensive agent, Eur J Pharm Biopharm. 1998, 46(2), 137-43.
  7. Astete C. E., Sabliov C. M.: Synthesis and characterization of PLGA Nanoparticles, J of Biomaterials Sci. 2006, 17(3), 247–289.

 

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