PLGA is a copolymer of lactide and glycolide, which is synthesized by irregular ring-opening polymerization. The degradation rate of PLGA is dependent on the amounts of glycolic acid and lactic acid. The degradation rate of PLGA is dependent on the amounts of glycolic acid and lactic acid. The PLGA containing a higher ratio of lactide is often less hydrophilic than PLGA containing an equal ratio of PLA and PGA or a lower ratio of PLA. This is because the presence of methyl side groups in PLA makes PLA more hydrophobic than PGA, and hence an increased ratio of PLA in PLGA copolymer would ultimately be less hydrophilic, absorb less water, and hence will degrade more slowly. This means that by varying the PLA content or by optimizing the hydrophilic content of PLGA, degradation time can be easily modulated.
The glass transition temperature (Tg) of the PLGA is more than 37°C and hence it is glassy in nature. The good mechanical strength of PLGA can be attributed to the rigid chain structure. The ratio of PLA in PLGA significantly affects the Tg of PLGA. With an increase in the ratio of PLA, Tg increases. Apart from its glassy nature, rigid chain structure, and hydrophilic nature, the physical properties of PLGA also depend on a variety of other factors such as the initial molecular weight, the ratio of lactide to glycolide, the size of the DDS, exposure to water (surface shape) and storage temperature; polydispersity and degree of crystallinity affect the biodegradation of PLGA and its mechanical strength . In the case of crystallinity, the ratio of PLA and PGA plays an important role
Formulation developers are using self-absorbable polymers to create drug delivery systems that improve the patient’s health Flexibility, convenience, and better compliance to meet patient needs can all be incorporated into the system design process involving the use of Proteins, vaccines, and other biological molecules. Scientists can use our polymer to develop & manufacture strategies for controlled release injectable depots, micro/nanoparticles, and solid implants. API together with polymer and solvent is mixed to form a gel which is injected into the patient so that the drug can release as per necessity.