Poly(lactic-co-glycolic acid) | PLGA | CAS 26780-50-7
Poly(lactic-co-glycolic acid) | PLGA | CAS 26780-50-7
Poly(lactic-co-glycolic acid), commonly known as PLGA, is the globally recognized "gold standard" among FDA-approved biodegradable and biocompatible polymers. Extensively utilized in novel drug delivery systems, PLGA offers unparalleled versatility for controlled-release formulations, making it the excipient of choice for next-generation pharmaceuticals, medical devices, and biotech innovations.
At Nomisma Healthcare, we manufacture ultrapure, lyophilized PLGA polymers engineered to meet the most rigorous demands of global pharmaceutical excellence. Whether you are developing long-acting injectables, targeted nanoparticles, or resorbable implants, our USP-recognized PLGA ensures safety, efficacy, and regulatory compliance.
Why Choose Nomisma Healthcare’s PLGA?
As a trusted leader in high-purity biodegradable excipients, we go beyond standard manufacturing. Our PLGA is designed to give formulators complete control over drug release kinetics and product stability.
- USP-Recognized Quality: Our polymers align with United States Pharmacopeia (USP) standards, and we provide comprehensive USP reverse engineering data to accelerate your regulatory filings.
- Unmatched Purity & Safety: We offer industry-leading low residual tin (≤ 50 ppm typical) using Sn-based catalysts, alongside specialized Tin-Free options for highly sensitive formulations.
- Advanced Grading: Choose from Sterile-grade and Low Bacterial Endotoxin options specifically designed for injectable depots and implantable medical devices.
- Total Customization: From tailored molecular weights to controlled block lengths and copolymer ratios, we engineer the polymer to fit your exact drug delivery profile.
Key Pharmaceutical & Biotech Applications
PLGA degrades into lactic acid and glycolic acid—natural byproducts already present in human metabolism via the citric acid cycle—ensuring exceptional biocompatibility. Our PLGA is heavily utilized in:
- Controlled-Release Drug Delivery: Formulating microspheres, nanoparticles, and implants for oncology, cardiovascular, and anti-inflammatory drugs.
- Protein & Peptide Therapeutics: Protecting fragile biologics and ensuring their sustained, stable release over weeks or months.
- Tissue Engineering & Regenerative Medicine: Serving as biocompatible, resorbable scaffolds for bone and tissue repair.
- Medical Devices & Cosmetics: Providing safe, bioresorbable structural components for next-generation healthcare and aesthetic products.
Technical Specifications & Customization Options
We offer a comprehensive portfolio of Poly(DL-lactide-co-glycolide) to suit diverse formulation needs.
|
Product Parameter |
Specification / Details |
|
Product Name |
Poly(DL-lactide-co-glycolide) / PLGA |
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Synonyms |
PLGA, PLG, LG Polymer, Poly(DL-lactic acid-co-glycolic acid), DL-Lactide/Glycolide Copolymer |
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CAS Number |
26780-50-7, 34346-01-5 |
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Available Forms |
Powder, Pellets, Microspheres, Custom particle-size controlled powder |
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Copolymer Ratios |
PLGA 50:50, 55:45, 65:35, 75:25, 85:15 |
|
Residual Tin |
≤ 50 ppm typical (Sn-based catalyst); Tin-free option available |
|
Available End Groups |
Acid terminated, Ester terminated, Lauryl ester, Ethyl ester, Hydroxyl (diol terminated), Glucose-initiated star polymer, Functional dye labeled polymers |
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Specialty Options |
Sterile grade, Low bacterial endotoxin, Custom molecular weight, Branched or star polymers |
Regulatory Compliance & Quality Assurance
Navigating the regulatory landscape for drug delivery systems requires excipients with impeccable documentation. Nomisma Healthcare provides full traceability, Certificates of Analysis (CoA), and Technical Data Sheets (TDS) for every batch. Our commitment to quality ensures that your transition from R&D to commercial manufacturing is seamless and compliant with global health authorities.
Start Your Journey with Nomisma Healthcare
Powering innovation in pharmaceuticals, medical devices, cosmetics, and healthcare. Join the industry leaders who rely on our high-purity polymers to bring life-saving drugs to market.