APPLICATIONS

Nomisma offers bio-resorbable / Biodegradable polymers as an excipient in Parenteral Controlled Release Drug Delivery Systems & raw material for Medical Devices

MORE THAN 25 YEARS OF EXPERIENCE IN THE FIELD OF BIORESORSABLES POLYMERS

Bis(hydroxyl)-terminated PLA-PEG-PLA triblocks | Nasal packing

After sinus surgery, it is important to use nasal packing to help control bleeding and provide support to separate tissue and structure at the surgical site. The device comprises bis(hydroxyl)-terminated PLA-PEG-PLA. This device functions to fill nasal/sinus cavities following surgery or trauma and to keep mucosal surfaces separate during the healing process.

Poly(L-lactide-co-ε-caprolactone) | PLCL | CAS No : 65408-67-5

Poly(L-lactide-co-ε-caprolactone) | PLCL | CAS No : 65408-67-5 Poly(L-lactide-co-ε-caprolactone) | PLCL | CAS No : 65408-67-5 Biodegradable, biocompatible, and bioresorbable copolymer

Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer

Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer formulated into an injectable solution which forms a gel in situ to provide prolonged drug release

The hydrogel polymer is an application-tailored PLGA-PEG-PLGA triblock polymer

The hydrogel polymer is an application-tailored PLGA-PEG-PLGA triblock polymer.
The polymer molecule exhibits a hydrophilic core region and hydrophilic ends. An aqueous solution of this polymer is reverse thermosensitive, meaning it is fluid and injectable at room temperature and will rapidly form a hydrogel at body temperature (e.g. after subcutaneous injection).

Dissolution of PLGA

Dissolution of PLGA in different solvents depending on the L: G ratio. The PLGA dissolution depends on the polymer concentration, polymer molecular weight, and temperature. The information is based on a PLGA molecular weight of around 50 kDa and a concentration of...

Poly(D,L-lactide-co-glycolide) | PLGA acid | PLGA-COOH | Nomisma Healthcare

Poly(D,L-lactide-co-glycolide) | PLGA acid | PLGA-COOH | Nomisma Healthcare

PLGA | Physicochemical Properties

PLGA is a copolymer of lactide and glycolide, which is synthesized by irregular ring-opening polymerization. The degradation rate of PLGA is dependent on the amounts of glycolic acid and lactic acid. The degradation rate of PLGA is dependent on the amounts of glycolic...

Application : Drug Delivery

Formulation developers are using self-absorbable polymers to create drug delivery systems that improve the patient’s health. Flexibility, convenience and better compliance to meet patient needs can all be incorporated into the system design process involving the use...

Pioneer in Bioabsorbable polymers

Nomisma Healthcare is one of the world’s leading specialty polymers manufacturer and supplier companies. Serving customers in consumer and industrial markets. The keen, passionate, well-knowledge staff is committed to providing practical, innovative, and elegant...

Drug Delivery

      • Formulation developers are using self-absorbable polymers to create drug delivery systems that improve the patient’s health. Flexibility, convenience and better compliance to meet patient needs can all be incorporated into the system design process involving the use of Proteins, vaccines, and other biological molecules. Scientists can use our polymer to develop & manufacture strategies of controlled release injectable depots, micro/nanoparticles, and solid implants. API together with polymer and solvent is mixed to form a gel which is injected into the patient so that the drug can release as per necessity.
  • Poly (D, L-Lactide) (PDLLA)
  • Poly (D, L-Lactide-co-Glycolide) (PLGA)
  • Poly (D, L-Lactide-co-Glycolide-co-PEG) (PLGA-PEG-PLGA).
PLGA

Medical Devices

Bioresorbable Polymers are valuable additives inside the design and manufacture of Medical Devices such as:
Screws
Plates and Bone regeneration scaffolds
Staples and Sutures
Neural conduits
Hernia meshes
Stents
Device coatings
Dental and Ophthalmic treatments

  • Poly(L-Lactide) (PLLA)
  • Poly(ɛ-Caprolactone) (PCL)
  • Poly(L-Lactide-co-ɛ-Caprolactone) (PLCL).
  • Poly(Glycolide) (PGA)
PLGA

Poly (D, L-Lactide-co-Glycolide) (PLGA)

Synonym: PLGA, Poly(D,L-lactide-co-glycolide) ,Poly(DL-lactide-co-glycolide), PGLA

CAS Number: 26780-50-7

 The ratio of Lactide and Glycolide: PLGA 50:50, PLGA 75:25, PLGA 85:15, PLGA 55:45, PLGA 45:55, PLGA 55:45 Star Glucose, PLGA 90:10, PLGA 10:90, Or any custom ratio of La and GA.

Inherent viscosity (IV.) range: 0.15 dg/L to 2.3 dg/L

End Group: Acid terminated, Ester terminated, Hydroxy terminated, etc.

Poly (D, L-Lactide) (PDLLA)

Synonym: Polylactic acid, Poly(L-lactide), Poly(D,L-lactide) , Poly(D-lactide), PLA, PLLA, PDLA, PDA, PDLLA etc.

CAS Number: 33135-50-1

 The ratio of L Lactide and D-Lactide: PLLA 100: 00, PDLLA 50:50, PDLLA 75:25 ,PDLLA25:75 , PDLA 00:100 etc.

Inherent viscosity (IV.) range: 0.15 dg/L to 2.3 dg/L

End Group: Acid terminated, Ester terminated, Hydroxy terminated, etc.

PLGA

Other Polymers

All bioresorbable polymers can be custom produced with defined Chemical Structures, Molar Masses (Molecular Weight or Inherent viscosity) & Selective Terminal End groups. some are as below

  •  Poly (D, L-Lactide-co-Glycolide-co-PEG) (PLGA-PEG-PLGA)
  • Poly(ɛ-Caprolactone) (PCL)
  • Poly(L-Lactide-co-ɛ-Caprolactone) (PLCL).
  • Poly(Glycolide) (PGA),
  • PLGA-NH2
  • M-PEG-OH
  • M-PEG-PLGA
  • M-PEG-NH2
  • Polyaniline