Additional information
| Appearance | |
|---|---|
| Molecular Weight | 43,000 – 63,000 da |
| Inherent viscocity (IV) |
CL1005
PCL/ CL1005 is a Medical Grade copolymer of ε-caprolactone with an inherent viscosity between 0.50 – 0.70 dL/g. Biodegradable, biocompatible, and bioresorbable copolymer composed of ε-caprolactone. This semi-crystalline material has been used in the fabrication of research medical devices and research tissue engineering solutions, such as orthopedic or soft tissue fixation devices. Degradation of these materials has been thoroughly studied and has been shown to be safely resorbed by the body after implantation. Modification of molecular weight and polymer composition allows for control of the degradation rate and mechanical stability of the polymer.
Manufacturing Process:
Ring-Opening
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Peer Reviewed Papers
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Abstract: The biodegradable polymer poly(lactic-co-glycolic acid) (PLGA) is a biomaterial with great potential as a drug delivery carrier and a... Read More
Size Optimization Bromelain Loaded Nanocarriers by Box Behnken Design
ABSTRACT Bromelain (BRN) is an extensive product of investigation, regarded as effective naturally produced anticancer agents. Heterogeneity of tumors amongst... Read More
CENTRAL COMPOSITE FACE-CENTERED DESIGN-BASED FAVIPIRAVIR-LOADED PLGA
ABSTRACTObjective: The objective of this study is to fabricate favipiravir-loaded PLGA nanoparticulate systems that can increase the solubility along with... Read More
Inhalable dry powder containing lipid polymer hybrid nanoparticles of Nintedanib esylate: In vitro and in vivo evaluations
Abstract: The key objective of this research work was to develop and evaluate dry powder for inhalation containing lipid polymer... Read More
SURFACE MODIFIED POLYMERIC NANOPARTICLES FOR ENHANCING DRUG DELIVERY OF METHOTREXATE IN THE BRAIN BY BLOCKING EFFLUX TRANSPORTERS
Abstract: The aim of the present study was to develop, optimize, and evaluate methotrexate containing poloxamer 407 coated polymeric nanoparticles... Read More
Human beta defensin-2 loaded PLGA nanoparticles impregnated in collagen-chitosan composite scaffold for the management of diabetic wounds
Abstract Diabetic wound (DW) is the most devastating complication resulting in significant mortality and morbidity in diabetic patients. The standard... Read More
Formulation and Evaluation of Pralidoxime-PLGA Microspheres as Antidote against Organophosphorus Poisioning
Abstract Objective: The objective of the present work is to formulate and evaluate Pralidoxime chloride (PAM)-controlled release microspheres using poly... Read More
A tailored solution for localized drug delivery in liver cancer treatment
ABSTRACT Adjuvant chemotherapy is highly recommended for liver cancer to enhance survival rates due to its tendency to recur frequently.... Read More
**Methotrexate-loaded polymeric lipid hybrid nanoparticles (PLHNPs): a reliable drug delivery system for the treatment of glioblastoma
Polymeric lipid hybrid nanoparticles (PHLNPs) are core-shell nanoparticle structures made up of polymer cores and lipid shells that have properties similar to both polymeric nanoparticles and liposomes. Methotrexate (MTX) loaded PLHNPs containing tween 80, phosphatidylcholine, poly D,... Read More
**Statistically designed vitamin D3 Encapsulated PLGA **microspheres dispersed in thermoresponsive in-situ gel for nasal delivery
Vitamin D deficiency is a cause of concern across the world. It is a fat-soluble vitamin and exhibits two molecular forms (D2 and D3). The aim of the present study is the development and optimization of vitamin D3 loaded PLGA microspheres by using Box Behnken Design. Additionally, to enhance nasal... Read More