DLG554G | PLGA 55:45

CAS 26780-50-7

DLG554G | PLGA 55:45 star Glucose is a Pharma / Medical Grade copolymer of DL-lactide and Glycolide in a 55:45 molar ratio having an inherent viscosity midpoint of 0.45 dl/g. It is supplied in the form of white to light tan micronized powder. DLG554G | PLGA 55:45 is primarily used for the Octreotide Depot microsphere and other drug delivery applications.

 

Product Description

CAS Number26780-50-7
Systematic Name1, 4-Dioxane-2, 5-dione-1-DL-3, 6-dimethyl-1, 4-dioxane-2, 5-dione copolymer, Glycolide – lactide copolymer, Glycolide-DL-lactide copolymer, Glycolide-DL-lactide polymer, Lactide – glycolide copolymer, Lactomer, Poly(dl-lactide-co-glycolide), Poly(glycolide – lactide), Poly(glycolide-co-lactide), Polyglactin
Molecular Formula((C3H4O2)m x (C2H2O2)n x Glucose
EPA Registry Name 55:45 Poly(DL-lactide-co-glycolide), D-glucose
Former CAS Number(s):107760-14-5, 119652-89-0, 1255770-56-9, 130953-65-0, 31213-75-9, 339986-68-4
Substance TypePLGA 55:45 | Inherent Viscosity: 0.40-0.60 | D-Glucose terminated | Lactide : Glycolide 55:45 | Mw 40 kDa
Biodegradable Polymer, Excipient, Non-Active pharmaceutical ingredient, Nanoparticles.
SynonymPLGA, Poly(D,L-lactide-co-glycolide) acid terminated, 55:45 Poly(DL-lactide-co-glycolide), D-glucose
ApplicationsDrug delivery formulations, Octereotide Depot 1 month

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Specification

Appearance White to off-white powder
Solubility Freely soluble in methylene chloride. Insoluble in water.
FT NMR (PROTON) Should comply
FT IR Should comply
Lactide by NMR 55±2%
Glycolide by NMR 45±2%
Viscosity (1% in CHCl3) Between 0.40-0.60 dL/g
Residual monomer DL-Lactide ≤ 0.5 %
Residual monomer Glycolide ≤ 0.5 %
Residual solvent acetone ≤ 0.1 %
Residual solvent toluene ≤ 890 PPM
Total Residual solvent ≤ 1000 PPM
Acid number ≤6 mg KOH/g
Heavy metal ≤ 10 PPM
Tin ≤ 200 PPM
PS equivalent mol. weight Mw by GPC 45 KDa
Sulphated Ash ≤ 0.1 %
TAMC ≤ 2000 CFU/g
TYMC ≤ 200 CFU/g
Bacterial Endotoxins ≤ 2000 EU/g
Self life 2 Years
See also:PLGA 55:45