PLGA 85:15 | DLG8512E

DLG8512E is an ester-terminated Pharma / Medical Grade linear co-polymer of polycondesed DL-lactic acid and Glycolic acid OR linear co-polymer of ring-opening polymerisation of DL-lactide and Glycolide in an 85:15 molar ratio and with an inherent viscosity between 1.30 – 1.70 dl/g.

It is supplied in the form of white-coloured lyophilized powder.

Primarily utilized in parenteral formulations and medical devices. Its applications extend to tissue engineering, nanoparticle formulation, and microsphere formulation, among other diverse uses.

CAS Number:
26780-50-7

Manufacturing Process:
Ring-Opening

Molecular Formula:
(C3H4O2)m x (C2H2O2)n

Synonyms:
PLGA, Poly(D,L-lactide-co-glycolide) ester terminated

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Additional information

Former CAS Number(s)

107760-14-5, 119652-89-0, 1255770-56-9, 130953-65-0, 31213-75-9, 339986-68-4

EPA Registry Name

The polylactic acid-polyglycolic acid copolymer

Applications

Drug delivery formulations

Synonym(s)

1, 4-Dioxane-2, 5-dione copolymer, 5-dione-1-DL-3, 6-dimethyl-1, Glycolide – lactide copolymer, Glycolide-DL-lactide copolymer, Glycolide-DL-lactide polymer, Lactide – glycolide copolymer, Lactomer, Poly(DL-lactide-co-glycolide), Poly(glycolide – lactide), Poly(glycolide-co-lactide), Polyglactin

Substance Type

Biodegradable Polymer, Ester terminated, Excipient, Inherent Viscosity : 1.3 – 1.7 dL/g, Lactide : Glycolide 85:15, Nanoparticles, Non-Active pharmaceutical ingredient, PLGA 75:25

Appearance

Solubility

,

FT NMR (PROTON)

FT IR

Lactide by NMR

Glycolide by NMR

Viscosity (1% in CHCl3)

Residual monomer DL-Lactide

Residual monomer Glycolide

Residual solvent acetone

Residual solvent toluene

Acid number

Heavy metal

Tin

Sulphated Ash

TAMC

TYMC

Bacterial Endotoxins

Self life

End Group

Ester terminated

Molecular Weight

190,000 – 240,000 da

Ratio

lactide:glycolide (85:15)

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**Statistically designed vitamin D3 Encapsulated PLGA **microspheres dispersed in thermoresponsive in-situ gel for nasal delivery

Vitamin D deficiency is a cause of concern across the world. It is a fat-soluble vitamin and exhibits two molecular forms (D2 and D3). The aim of the present study is the development and optimization of vitamin D3 loaded PLGA microspheres by using Box Behnken Design. Additionally, to enhance nasal... Read More

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